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The tcplfit2 R package performs basic concentration-response curve fitting. The original tcplFit() function in the ToxCast Data Analysis Pipeline (tcpl) R package performed basic concentration-response curvefitting to 3 models. With tcplfit2, the core tcpl concentration-response functionality has been expanded to process diverse high-throughput screen (HTS) data generated at the US Environmental Protection Agency, including targeted ToxCast, high-throughput transcriptomics (HTTr) and high-throughput phenotypic profiling (HTPP). tcplfit2 can be used independently to support analysis for diverse chemical screening efforts.
If you are interested in contributing or want to report a bug, please submit a issue or start a discussion.
To install the current development version, run the following command:
devtools::install_github("USEPA/CompTox-ToxCast-tcplfit2")These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.