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Two-Phase Genetic Association Study design and analysis with missing covariates by design
Provides functionality for selecting and analyzing individuals in two-phase genetic association studies. Phase 1 data usually come from GWAS results and we assume phase 2 genetic data will be part of a targeted genome sequencing/fine-mapping study. The package assists in selecting a subset of individuals that will be sequenced for phase 2. Once phase 2 data have been collected, the package implements methods to analyze phase 1 and 2 data together using semi-parametric regression models.
You can install the current version of twoPhaseGAS from
GitHub using (devtools
required):
devtools::install_github("egosv/twoPhaseGAS", ref="main")These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.