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Randomization Based Methods for Covariance and Stratified Adjustment of Win Ratios and Win Odds for Ordinal Outcomes
Ann Marie K. Weideman, Elaine K. Kowalewski, Gary G. Koch
Ann Marie Weideman, anndo1(at)umbc.edu
An R package that performs randomization-based adjustment of the win ratio and win odds for covariates and strata.
Inputs: * data: a dataframe or matrix
containing the analysis data. Must be in wide format such that a
participant’s repeated responses are in a single row, and each response
is in a separate column. * pid: a string indicating the
name of the variable corresponding to participant ID. *
baseline: a string indicating the name of the outcome
measured at baseline. If not specified, defaults to NULL, and no
baseline adjustment is employed. * outcome: a vector of
strings indicating the names of the outcomes measured at each visit.
Baseline, if specified, will be concatenated to this vector within the
code. The outcomes must have at least an ordinal measurement scale with
larger values being better than smaller values. Thus, the outcome can be
ordered categories or continuous measurements. * covars: a
vector of strings indicating the names of the covariates (measured at
baseline) used for adjustment. These covariates must be numeric and can
be measured on a binary, categorical, ordered categorical, or continuous
scale. If not specified, defaults to NULL and no covariate adjustment is
employed. * strata: a string indicating the name of the
variable used for stratification. If not specified, defaults to NULL and
no stratification is utilized. * arm: a string indicating
the name of the variable for treatment arm. Treatment arm must be a
positive integer such that the test treatment arm is ALWAYS higher in
value than the control arm. * method: a string “small” or
“large” used to denote the method employed. The small sample size method
is recommended unless within-stratum sample size is reasonably large
(e.g., >= 50), number of visits is small (e.g., <=6), and number
of covariates is small (e.g., <=4). Defaults to “small.” *
sig.level: significance level (Type I error probability).
Defaults to 0.05.
Outputs: A dataframe containing *
logWR: natural log-transformed win ratio *
SE_logWR: standard error of log-transformed win ratio *
Var_logWR: sample variance of log-transformed win ratio *
Chi_Square: Pearson’s Chi-squared test statistic
corresponding to logWR * p_value: p-value
corresponding to the Pearson’s Chi-squared test * WR: win
ratio * LCL_WR: lower bound of \((1-\alpha)\times 100\)% CI for
WR * UCL_WR: upper bound of \((1-\alpha)\times 100\)% CI for
WR
Install the current release from CRAN (not recommended). Not published on CRAN as of 11/30/23:
install.packages("winr")Install the developmental version from GitHub (HIGHLY recommended, as this will allow you to install any bugs that were corrected post-publication to CRAN)
if (!require("devtools", character.only = TRUE)) {
install.packages("devtools", dependencies = TRUE)
}
library("devtools", character.only = TRUE)
devtools::install_github("annweideman/winr")These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.