wnl: Minimization Tool for Pharmacokinetic-Pharmacodynamic Data Analysis

This is a set of minimization tools (maximum likelihood estimation and least square fitting) to solve examples in the Johan Gabrielsson and Dan Weiner's book "Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications" 5th ed. (ISBN:9198299107). Examples include linear and nonlinear compartmental model, turn-over model, single or multiple dosing bolus/infusion/oral models, allometry, toxicokinetics, reversible metabolism, in-vitro/in-vivo extrapolation, enterohepatic circulation, metabolite modeling, Emax model, inhibitory model, tolerance model, oscillating response model, enantiomer interaction model, effect compartment model, drug-drug interaction model, receptor occupancy model, and rebound phenomena model.

Version:	0.8.1
Depends:	R (≥ 3.5.0), numDeriv
Published:	2024-06-01
DOI:	10.32614/CRAN.package.wnl
Author:	Kyun-Seop Bae [aut]
Maintainer:	Kyun-Seop Bae <k at acr.kr>
License:	GPL-3
Copyright:	2017-, Kyun-Seop Bae
URL:	https://cran.r-project.org/package=wnl
NeedsCompilation:	no
Materials:	NEWS
In views:	Pharmacokinetics
CRAN checks:	wnl results

Documentation:

Reference manual:

wnl.pdf

Downloads:

Package source:	wnl_0.8.1.tar.gz
Windows binaries:	r-devel: wnl_0.8.1.zip, r-release: wnl_0.8.1.zip, r-oldrel: wnl_0.8.1.zip
macOS binaries:	r-release (arm64): wnl_0.8.1.tgz, r-oldrel (arm64): wnl_0.8.1.tgz, r-release (x86_64): wnl_0.8.1.tgz, r-oldrel (x86_64): wnl_0.8.1.tgz
Old sources:	wnl archive

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