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Implementation of LT-FH++, an extension of the liability threshold family history (LT-FH) model. LT-FH++ uses a Gibbs sampler for sampling from the truncated multivariate normal distribution and allows for flexible family structures. LT-FH++ was first described in Pedersen, Emil M., et al. (2022) <https://pure.au.dk/ws/portalfiles/portal/353346245/> as an extension to LT-FH with more flexible family structures, and again as the age-dependent liability threshold (ADuLT) model Pedersen, Emil M., et al. (2023) <https://www.nature.com/articles/s41467-023-41210-z> as an alternative to traditional time-to-event genome-wide association studies, where family history was not considered.
| Version: | 2.1.1 |
| Imports: | batchmeans, dplyr, future.apply, future, purrr, Rcpp, rlang, stats, stringr, tibble, tmvtnorm, tidyselect, igraph, xgboost, tidyr |
| LinkingTo: | Rcpp |
| Suggests: | MASS, knitr, rmarkdown, testthat |
| Published: | 2024-02-12 |
| DOI: | 10.32614/CRAN.package.LTFHPlus |
| Author: | Emil Michael Pedersen [aut, cre], Florian Privé [aut, ths], Bjarni Jóhann Vilhjálmsson [ths], Esben Agerbo [ths], Jette Steinbach [aut], Lucas Rasmussen [ctb] |
| Maintainer: | Emil Michael Pedersen <emp at ph.au.dk> |
| BugReports: | https://github.com/EmilMiP/LTFHPlus/issues |
| License: | GPL-3 |
| URL: | https://github.com/EmilMiP/LTFHPlus |
| NeedsCompilation: | yes |
| Language: | "en-GB" |
| Materials: | README NEWS |
| CRAN checks: | LTFHPlus results |
| Reference manual: | LTFHPlus.pdf |
| Package source: | LTFHPlus_2.1.1.tar.gz |
| Windows binaries: | r-devel: LTFHPlus_2.1.1.zip, r-release: LTFHPlus_2.1.1.zip, r-oldrel: LTFHPlus_2.1.1.zip |
| macOS binaries: | r-release (arm64): LTFHPlus_2.1.1.tgz, r-oldrel (arm64): LTFHPlus_2.1.1.tgz, r-release (x86_64): LTFHPlus_2.1.1.tgz, r-oldrel (x86_64): LTFHPlus_2.1.1.tgz |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.