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LocalControl: Nonparametric Methods for Generating High Quality Comparative Effectiveness Evidence

Implements novel nonparametric approaches to address biases and confounding when comparing treatments or exposures in observational studies of outcomes. While designed and appropriate for use in studies involving medicine and the life sciences, the package can be used in other situations involving outcomes with multiple confounders. The package implements a family of methods for non-parametric bias correction when comparing treatments in observational studies, including survival analysis settings, where competing risks and/or censoring may be present. The approach extends to bias-corrected personalized predictions of treatment outcome differences, and analysis of heterogeneity of treatment effect-sizes across patient subgroups. For further details, please see: Lauve NR, Nelson SJ, Young SS, Obenchain RL, Lambert CG. LocalControl: An R Package for Comparative Safety and Effectiveness Research. Journal of Statistical Software. 2020. p. 1–32. Available from <doi:10.18637/jss.v096.i04>.

Version: 1.1.4
Depends: R (≥ 3.0.0)
Imports: Rcpp, gss, cluster, lattice, stats, graphics
LinkingTo: Rcpp
Suggests: colorspace, RColorBrewer, data.table, ggplot2, gridExtra, rpart, rpart.plot, xtable, knitr
Published: 2024-09-04
DOI: 10.32614/CRAN.package.LocalControl
Author: Nicolas R. Lauve ORCID iD [aut], Stuart J. Nelson ORCID iD [aut], S. Stanley Young ORCID iD [aut], Robert L. Obenchain ORCID iD [aut], Melania Pintilie [ctb], Martin Kutz [ctb], Christophe G. Lambert ORCID iD [aut, cre]
Maintainer: Christophe G. Lambert <cglambert at salud.unm.edu>
BugReports: https://github.com/OHDSI/LocalControl/issues
License: Apache License 2.0 | file LICENSE
URL: https://github.com/OHDSI/LocalControl
NeedsCompilation: yes
Citation: LocalControl citation info
Materials: README NEWS
CRAN checks: LocalControl results

Documentation:

Reference manual: LocalControl.pdf
Vignettes: LocalControl-jss-2020 (source, R code)

Downloads:

Package source: LocalControl_1.1.4.tar.gz
Windows binaries: r-devel: LocalControl_1.1.4.zip, r-release: LocalControl_1.1.4.zip, r-oldrel: LocalControl_1.1.4.zip
macOS binaries: r-release (arm64): LocalControl_1.1.4.tgz, r-oldrel (arm64): LocalControl_1.1.4.tgz, r-release (x86_64): LocalControl_1.1.4.tgz, r-oldrel (x86_64): LocalControl_1.1.4.tgz
Old sources: LocalControl archive

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.