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MBNMAdose: Dose-Response MBNMA Models

Fits Bayesian dose-response model-based network meta-analysis (MBNMA) that incorporate multiple doses within an agent by modelling different dose-response functions, as described by Mawdsley et al. (2016) <doi:10.1002/psp4.12091>. By modelling dose-response relationships this can connect networks of evidence that might otherwise be disconnected, and can improve precision on treatment estimates. Several common dose-response functions are provided; others may be added by the user. Various characteristics and assumptions can be flexibly added to the models, such as shared class effects. The consistency of direct and indirect evidence in the network can be assessed using unrelated mean effects models and/or by node-splitting at the treatment level.

Version: 0.5.0
Depends: R (≥ 3.0.2)
Imports: grDevices, stats, graphics, utils, scales, dplyr (≥ 0.7.4), R2jags (≥ 0.5-7), rjags (≥ 4-8), magrittr (≥ 1.5), checkmate (≥ 1.8.5), Rdpack (≥ 0.11-0), igraph (≥ 2.0.1.1), ggplot2 (≥ 2.2.1), reshape2 (≥ 1.4.3)
Suggests: overlapping (≥ 1.5.0), RColorBrewer (≥ 1.1-2), mcmcplots (≥ 0.4.3), coda (≥ 0.19-4), testthat (≥ 1.0.2), crayon (≥ 1.3.4), forestplot (≥ 1.10), ggdist (≥ 2.4.0), zoo (≥ 1.8-8), lspline (≥ 1.0-0), formatR (≥ 1.14), netmeta, knitr, rmarkdown
Published: 2025-02-07
DOI: 10.32614/CRAN.package.MBNMAdose
Author: Hugo Pedder ORCID iD [aut, cre], Adil Karim [ctb]
Maintainer: Hugo Pedder <hugopedder at gmail.com>
License: GPL-3
URL: https://hugaped.github.io/MBNMAdose/
NeedsCompilation: no
SystemRequirements: JAGS (>= 4.3.0) (https://mcmc-jags.sourceforge.net/)
Language: en-GB
Citation: MBNMAdose citation info
Materials: README NEWS
In views: MetaAnalysis
CRAN checks: MBNMAdose results

Documentation:

Reference manual: MBNMAdose.pdf
Vignettes: MBNMAdose: Checking for consistency (source, R code)
MBNMAdose: Exploring the data (source, R code)
MBNMAdose: Package Overview (source, R code)
MBNMAdose: Perform Network Meta-Regression (source, R code)
Class effect NMA analysis using MBNMAdose (source, R code)
MBNMAdose outputs: Relative effects, forest plots and rankings (source, R code)
MBNMAdose: Calculating model predictions (source, R code)
MBNMAdose: Perform a Model-Based Network Meta-Analysis (MBNMA) (source, R code)

Downloads:

Package source: MBNMAdose_0.5.0.tar.gz
Windows binaries: r-devel: MBNMAdose_0.5.0.zip, r-release: MBNMAdose_0.5.0.zip, r-oldrel: MBNMAdose_0.5.0.zip
macOS binaries: r-devel (arm64): MBNMAdose_0.5.0.tgz, r-release (arm64): MBNMAdose_0.5.0.tgz, r-oldrel (arm64): MBNMAdose_0.5.0.tgz, r-devel (x86_64): MBNMAdose_0.5.0.tgz, r-release (x86_64): MBNMAdose_0.5.0.tgz, r-oldrel (x86_64): MBNMAdose_0.5.0.tgz
Old sources: MBNMAdose archive

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.