Mediana: Clinical Trial Simulations

Provides a general framework for clinical trial simulations based on the Clinical Scenario Evaluation (CSE) approach. The package supports a broad class of data models (including clinical trials with continuous, binary, survival-type and count-type endpoints as well as multivariate outcomes that are based on combinations of different endpoints), analysis strategies and commonly used evaluation criteria.

Version:	1.0.8
Imports:	doParallel, doRNG, foreach, MASS, mvtnorm, stats, survival, utils
Suggests:	flextable, knitr, officer, rmarkdown, pander
Published:	2019-05-08
DOI:	10.32614/CRAN.package.Mediana
Author:	Gautier Paux, Alex Dmitrienko.
Maintainer:	Gautier Paux <gautier at paux.fr>
BugReports:	https://github.com/gpaux/Mediana/issues
License:	GPL-2
URL:	http://gpaux.github.io/Mediana/
NeedsCompilation:	no
Materials:	README NEWS
In views:	ClinicalTrials
CRAN checks:	Mediana results

Documentation:

Reference manual:	Mediana.pdf
Vignettes:	Adjusted p-values and one-sided simultaneous confidence limits Case studies Mediana: an R package for clinical trial simulations

Downloads:

Package source:	Mediana_1.0.8.tar.gz
Windows binaries:	r-devel: Mediana_1.0.8.zip, r-release: Mediana_1.0.8.zip, r-oldrel: Mediana_1.0.8.zip
macOS binaries:	r-release (arm64): Mediana_1.0.8.tgz, r-oldrel (arm64): Mediana_1.0.8.tgz, r-release (x86_64): Mediana_1.0.8.tgz, r-oldrel (x86_64): Mediana_1.0.8.tgz
Old sources:	Mediana archive

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