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Mediana: Clinical Trial Simulations

Provides a general framework for clinical trial simulations based on the Clinical Scenario Evaluation (CSE) approach. The package supports a broad class of data models (including clinical trials with continuous, binary, survival-type and count-type endpoints as well as multivariate outcomes that are based on combinations of different endpoints), analysis strategies and commonly used evaluation criteria.

Version: 1.0.8
Imports: doParallel, doRNG, foreach, MASS, mvtnorm, stats, survival, utils
Suggests: flextable, knitr, officer, rmarkdown, pander
Published: 2019-05-08
DOI: 10.32614/CRAN.package.Mediana
Author: Gautier Paux, Alex Dmitrienko.
Maintainer: Gautier Paux <gautier at paux.fr>
BugReports: https://github.com/gpaux/Mediana/issues
License: GPL-2
URL: http://gpaux.github.io/Mediana/
NeedsCompilation: no
Materials: README NEWS
In views: ClinicalTrials
CRAN checks: Mediana results

Documentation:

Reference manual: Mediana.pdf
Vignettes: Adjusted p-values and one-sided simultaneous confidence limits
Case studies
Mediana: an R package for clinical trial simulations

Downloads:

Package source: Mediana_1.0.8.tar.gz
Windows binaries: r-devel: Mediana_1.0.8.zip, r-release: Mediana_1.0.8.zip, r-oldrel: Mediana_1.0.8.zip
macOS binaries: r-release (arm64): Mediana_1.0.8.tgz, r-oldrel (arm64): Mediana_1.0.8.tgz, r-release (x86_64): Mediana_1.0.8.tgz, r-oldrel (x86_64): Mediana_1.0.8.tgz
Old sources: Mediana archive

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.