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Implements large-scale hypothesis testing by variance mixing. It takes two statistics per testing unit – an estimated effect and its associated squared standard error – and fits a nonparametric, shape-constrained mixture separately on two latent parameters. It reports local false discovery rates (lfdr) and local false sign rates (lfsr). Manuscript describing algorithm of MixTwice: Zheng et al(2021) <doi:10.1093/bioinformatics/btab162>.
Version: | 2.0 |
Depends: | R (≥ 3.5.0) |
Imports: | alabama, ashr, fdrtool, Iso, stats |
Published: | 2022-03-02 |
DOI: | 10.32614/CRAN.package.MixTwice |
Author: | Zihao Zheng and Michael A.Newton |
Maintainer: | Zihao Zheng <zihao.zheng at wisc.edu> |
License: | GPL-2 |
NeedsCompilation: | no |
CRAN checks: | MixTwice results |
Reference manual: | MixTwice.pdf |
Package source: | MixTwice_2.0.tar.gz |
Windows binaries: | r-devel: MixTwice_2.0.zip, r-release: MixTwice_2.0.zip, r-oldrel: MixTwice_2.0.zip |
macOS binaries: | r-release (arm64): MixTwice_2.0.tgz, r-oldrel (arm64): MixTwice_2.0.tgz, r-release (x86_64): MixTwice_2.0.tgz, r-oldrel (x86_64): MixTwice_2.0.tgz |
Old sources: | MixTwice archive |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.