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Contains three simulation functions for implementing the entire Phase 123 trial and the separate Eff-Tox and Phase 3 portions of the trial, which may be beneficial for use on clusters. The functions AssignEffTox() and RandomizeEffTox() assign doses to patient cohorts during phase 12 and Reoptimize() determines the optimal dose to continue with during Phase 3. The functions ReturnMeansAgent() and ReturnMeanControl() gives the true mean survival for the agent doses and control and ReturnOCS() gives the operating characteristics of the design.
| Version: | 2.1 |
| Imports: | Rcpp (≥ 0.12.9), survival, stats |
| LinkingTo: | Rcpp, RcppArmadillo |
| Published: | 2019-04-25 |
| DOI: | 10.32614/CRAN.package.Phase123 |
| Author: | Andrew G Chapple |
| Maintainer: | Andrew G Chapple <achapp at lsuhsc.edu> |
| License: | GPL-2 |
| NeedsCompilation: | yes |
| CRAN checks: | Phase123 results |
| Reference manual: | Phase123.pdf |
| Package source: | Phase123_2.1.tar.gz |
| Windows binaries: | r-devel: Phase123_2.1.zip, r-release: Phase123_2.1.zip, r-oldrel: Phase123_2.1.zip |
| macOS binaries: | r-release (arm64): Phase123_2.1.tgz, r-oldrel (arm64): Phase123_2.1.tgz, r-release (x86_64): Phase123_2.1.tgz, r-oldrel (x86_64): Phase123_2.1.tgz |
| Old sources: | Phase123 archive |
| Reverse imports: | UtilityFrailtyPH12 |
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These binaries (installable software) and packages are in development.
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