The hardware and bandwidth for this mirror is donated by METANET, the Webhosting and Full Service-Cloud Provider.
If you wish to report a bug, or if you are interested in having us mirror your free-software or open-source project, please feel free to contact us at mirror[@]metanet.ch.

TANDEM: A Two-Stage Approach to Maximize Interpretability of Drug Response Models Based on Multiple Molecular Data Types

A two-stage regression method that can be used when various input data types are correlated, for example gene expression and methylation in drug response prediction. In the first stage it uses the upstream features (such as methylation) to predict the response variable (such as drug response), and in the second stage it uses the downstream features (such as gene expression) to predict the residuals of the first stage. In our manuscript (Aben et al., 2016, <doi:10.1093/bioinformatics/btw449>), we show that using TANDEM prevents the model from being dominated by gene expression and that the features selected by TANDEM are more interpretable.

Version: 1.0.3
Depends: R (≥ 2.10)
Imports: glmnet (≥ 3.0), Matrix
Suggests: knitr, rmarkdown
Published: 2019-11-25
DOI: 10.32614/CRAN.package.TANDEM
Author: Nanne Aben
Maintainer: Nanne Aben <nanne.aben at gmail.com>
License: GPL-2
NeedsCompilation: no
Materials: README NEWS
CRAN checks: TANDEM results

Documentation:

Reference manual: TANDEM.pdf
Vignettes: TANDEM

Downloads:

Package source: TANDEM_1.0.3.tar.gz
Windows binaries: r-devel: TANDEM_1.0.3.zip, r-release: TANDEM_1.0.3.zip, r-oldrel: TANDEM_1.0.3.zip
macOS binaries: r-release (arm64): TANDEM_1.0.3.tgz, r-oldrel (arm64): TANDEM_1.0.3.tgz, r-release (x86_64): TANDEM_1.0.3.tgz, r-oldrel (x86_64): TANDEM_1.0.3.tgz
Old sources: TANDEM archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=TANDEM to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.