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Provides the functions for planning and conducting a clinical trial with adaptive sample size determination. Maximal statistical efficiency will be exploited even when dramatic or multiple adaptations are made. Such a trial consists of adaptive determination of sample size at an interim analysis and implementation of frequentist statistical test at the interim and final analysis with a prefixed significance level. The required assumptions for the stage-wise test statistics are independent and stationary increments and normality. Predetermination of adaptation rule is not required.
Version: | 0.1.2 |
Depends: | R (≥ 3.5.0) |
Imports: | Rcpp (≥ 0.12.17) |
LinkingTo: | Rcpp (≥ 0.12.17) |
Suggests: | knitr, rmarkdown |
Published: | 2022-12-09 |
DOI: | 10.32614/CRAN.package.adpss |
Author: | Kosuke Kashiwabara [aut, cre] |
Maintainer: | Kosuke Kashiwabara <kashiwabara-tky at umin.ac.jp> |
License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
URL: | https://github.com/ca4wa/R-adpss |
NeedsCompilation: | yes |
Materials: | README NEWS |
CRAN checks: | adpss results |
Reference manual: | adpss.pdf |
Vignettes: |
Illustration of adaptive sample size determination |
Package source: | adpss_0.1.2.tar.gz |
Windows binaries: | r-devel: adpss_0.1.2.zip, r-release: adpss_0.1.2.zip, r-oldrel: adpss_0.1.2.zip |
macOS binaries: | r-release (arm64): adpss_0.1.2.tgz, r-oldrel (arm64): adpss_0.1.2.tgz, r-release (x86_64): adpss_0.1.2.tgz, r-oldrel (x86_64): adpss_0.1.2.tgz |
Old sources: | adpss archive |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.