amp.sim: Flexible Simulation Utilities for Pharmacometric Modeling

The goal of 'amp.sim' is to transform 'NONMEM' models into R syntax so they can be used for simulations using the 'deSolve', 'nlmixr2' or 'mrgsolve' package. Additionally, functionality is included to aid simulations performed directly in 'NONMEM' and to automatically create shiny apps for simulation models.

Version:	0.1.1
Depends:	R (≥ 4.1.0)
Imports:	stats, utils, MASS, whisker, rlang, cli, lifecycle, NMdata (≥ 0.2.3)
Suggests:	nonmem2rx, tidyr, shiny, shinyjs, bslib, rstudioapi, deSolve, rxode2, mrgsolve, R3port, ggplot2, dplyr, testthat, quarto
Published:	2026-05-11
DOI:	10.32614/CRAN.package.amp.sim
Author:	Richard Hooijmaijers [aut, cre, cph], LAPP Consultants [fnd, cph]
Maintainer:	Richard Hooijmaijers <richardhooijmaijers at gmail.com>
BugReports:	https://github.com/LeidenAdvancedPKPD/amp.sim/issues
License:	GPL (≥ 3)
URL:	https://leidenadvancedpkpd.github.io/amp.sim/, https://github.com/LeidenAdvancedPKPD/amp.sim
NeedsCompilation:	no
Materials:	README, NEWS
CRAN checks:	amp.sim results [issues need fixing before 2026-05-25]

Documentation:

Reference manual:	amp.sim.html , amp.sim.pdf
Vignettes:	Simulations using R (source, R code) Simulations using NONMEM (source, R code) Shiny apps (source, R code) Considerations for translating models (source, R code)

Downloads:

Package source:	amp.sim_0.1.1.tar.gz
Windows binaries:	r-devel: amp.sim_0.1.1.zip, r-release: amp.sim_0.1.0.zip, r-oldrel: amp.sim_0.1.1.zip
macOS binaries:	r-release (arm64): amp.sim_0.1.1.tgz, r-oldrel (arm64): amp.sim_0.1.1.tgz, r-release (x86_64): amp.sim_0.1.1.tgz, r-oldrel (x86_64): amp.sim_0.1.1.tgz
Old sources:	amp.sim archive

Linking:

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