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blisa: Infer Cell-Cell Communication from Spatial Transcriptomics

Identifies cell-cell communication hotspots in spatial transcriptomics data using bivariate Local Moran's I statistics on hexagonally binned cells. Provides functions for spatial weighting, ligand-receptor pair filtering, hotspot detection, and visualisation of sender-receiver cell-type interactions.

Version: 0.2.0
Imports: sf, spdep, Matrix, SpatialExperiment, SummarizedExperiment, ComplexHeatmap, ggplot2, viridisLite, grid
Suggests: knitr, rmarkdown
Published: 2026-06-02
DOI: 10.32614/CRAN.package.blisa
Author: Yunshun Chen [aut, cre], Lei Qin [aut], Lizhong Chen [aut]
Maintainer: Yunshun Chen <yuchen at wehi.edu.au>
License: GPL (≥ 3)
NeedsCompilation: no
Materials: README
CRAN checks: blisa results

Documentation:

Reference manual: blisa.html , blisa.pdf
Vignettes: BLISA Workflow (source, R code)

Downloads:

Package source: blisa_0.2.0.tar.gz
Windows binaries: r-devel: blisa_0.2.0.zip, r-release: blisa_0.2.0.zip, r-oldrel: blisa_0.2.0.zip
macOS binaries: r-release (arm64): blisa_0.2.0.tgz, r-oldrel (arm64): blisa_0.2.0.tgz, r-release (x86_64): blisa_0.2.0.tgz, r-oldrel (x86_64): blisa_0.2.0.tgz

Linking:

Please use the canonical form https://CRAN.R-project.org/package=blisa to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.