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crmPack: Object-Oriented Implementation of CRM Designs

Implements a wide range of model-based dose escalation designs, ranging from classical and modern continual reassessment methods (CRMs) based on dose-limiting toxicity endpoints to dual-endpoint designs taking into account a biomarker/efficacy outcome. The focus is on Bayesian inference, making it very easy to setup a new design with its own JAGS code. However, it is also possible to implement 3+3 designs for comparison or models with non-Bayesian estimation. The whole package is written in a modular form in the S4 class system, making it very flexible for adaptation to new models, escalation or stopping rules.

Version: 1.0.6
Depends: R (≥ 3.0.0), ggplot2 (≥ 2.0.0), graphics
Imports: methods, grid, gridExtra, GenSA, mvtnorm, parallel, rjags, utils, tools, MASS
Suggests: ggmcmc, knitr, Rcpp, RcppArmadillo
Published: 2024-06-26
DOI: 10.32614/CRAN.package.crmPack
Author: Daniel Sabanes Bove [aut, cre], Wai Yin Yeung [aut], Giuseppe Palermo [aut], Thomas Jaki [aut]
Maintainer: Daniel Sabanes Bove <daniel.sabanes_bove at rconis.com>
BugReports: https://github.com/openpharma/crmPack/issues
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
Copyright: F. Hoffmann-La Roche Ltd
URL: https://github.com/openpharma/crmPack
NeedsCompilation: no
Citation: crmPack citation info
Materials: NEWS
In views: ClinicalTrials, ExperimentalDesign
CRAN checks: crmPack results

Documentation:

Reference manual: crmPack.pdf
Vignettes: Guidelines for developers and maintainer
crmPack: Object-oriented implementation of CRM designs

Downloads:

Package source: crmPack_1.0.6.tar.gz
Windows binaries: r-devel: crmPack_1.0.6.zip, r-release: crmPack_1.0.6.zip, r-oldrel: crmPack_1.0.6.zip
macOS binaries: r-release (arm64): crmPack_1.0.6.tgz, r-oldrel (arm64): crmPack_1.0.6.tgz, r-release (x86_64): crmPack_1.0.6.tgz, r-oldrel (x86_64): crmPack_1.0.6.tgz
Old sources: crmPack archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=crmPack to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.