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Software of 'esDesign' is developed to implement the adaptive enrichment designs with sample size re-estimation presented in Lin et al. (2021) <doi:10.1016/j.cct.2020.106216>. In details, three-proposed trial designs are provided, including the AED1-SSR (or ES1-SSR), AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition, this package also contains several widely used adaptive designs, such as the Marker Sequential Test (MaST) design proposed Freidlin et al. (2014) <doi:10.1177/1740774513503739>, the adaptive enrichment designs without early stopping (AED or ES), the sample size re-estimation procedure (SSR) based on the conditional power proposed by Proschan and Hunsberger (1995), and some useful functions. In details, we can calculate the futility and/or efficacy stopping boundaries, the sample size required, calibrate the value of the threshold of the difference between subgroup-specific test statistics, conduct the simulation studies in AED, SSR, AED1-SSR, AED2-SSR and AED3-SSR.
| Version: | 1.0.3 |
| Depends: | R (≥ 3.2.0) |
| Imports: | stats |
| Suggests: | knitr, rmarkdown |
| Published: | 2021-07-13 |
| Author: | Zhao Yang, Ruitao Lin, Guosheng Yin and Ying Yuan |
| Maintainer: | Zhao Yang <yangz98 at connect.hku.hk> |
| License: | GPL-2 |
| NeedsCompilation: | no |
| Materials: | NEWS |
| CRAN checks: | esDesign results |
| Reference manual: | esDesign.pdf |
| Package source: | esDesign_1.0.3.tar.gz |
| Windows binaries: | r-devel: esDesign_1.0.3.zip, r-release: esDesign_1.0.3.zip, r-oldrel: esDesign_1.0.3.zip |
| macOS binaries: | r-release (arm64): esDesign_1.0.3.tgz, r-oldrel (arm64): esDesign_1.0.3.tgz, r-release (x86_64): esDesign_1.0.3.tgz, r-oldrel (x86_64): esDesign_1.0.3.tgz |
| Old sources: | esDesign archive |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.