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esDesign: Adaptive Enrichment Designs with Sample Size Re-Estimation

Software of 'esDesign' is developed to implement the adaptive enrichment designs with sample size re-estimation presented in Lin et al. (2021) <doi:10.1016/j.cct.2020.106216>. In details, three-proposed trial designs are provided, including the AED1-SSR (or ES1-SSR), AED2-SSR (or ES2-SSR) and AED3-SSR (or ES3-SSR). In addition, this package also contains several widely used adaptive designs, such as the Marker Sequential Test (MaST) design proposed Freidlin et al. (2014) <doi:10.1177/1740774513503739>, the adaptive enrichment designs without early stopping (AED or ES), the sample size re-estimation procedure (SSR) based on the conditional power proposed by Proschan and Hunsberger (1995), and some useful functions. In details, we can calculate the futility and/or efficacy stopping boundaries, the sample size required, calibrate the value of the threshold of the difference between subgroup-specific test statistics, conduct the simulation studies in AED, SSR, AED1-SSR, AED2-SSR and AED3-SSR.

Version: 1.0.3
Depends: R (≥ 3.2.0)
Imports: stats
Suggests: knitr, rmarkdown
Published: 2021-07-13
DOI: 10.32614/CRAN.package.esDesign
Author: Zhao Yang, Ruitao Lin, Guosheng Yin and Ying Yuan
Maintainer: Zhao Yang <yangz98 at connect.hku.hk>
License: GPL-2
NeedsCompilation: no
Materials: NEWS
CRAN checks: esDesign results

Documentation:

Reference manual: esDesign.pdf

Downloads:

Package source: esDesign_1.0.3.tar.gz
Windows binaries: r-devel: esDesign_1.0.3.zip, r-release: esDesign_1.0.3.zip, r-oldrel: esDesign_1.0.3.zip
macOS binaries: r-release (arm64): esDesign_1.0.3.tgz, r-oldrel (arm64): esDesign_1.0.3.tgz, r-release (x86_64): esDesign_1.0.3.tgz, r-oldrel (x86_64): esDesign_1.0.3.tgz
Old sources: esDesign archive

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.