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Quantifying similarity between high-dimensional single cell samples is challenging, and usually requires some simplifying hypothesis to be made. By transforming the high dimensional space into a high dimensional grid, the number of cells in each sub-space of the grid is characteristic of a given sample. Using a Hilbert curve each sample can be visualized as a simple density plot, and the distance between samples can be calculated from the distribution of cells using the Jensen-Shannon distance. Bins that correspond to significant differences between samples can identified using a simple bootstrap procedure.
Version: | 0.4.3 |
Imports: | Rcpp, entropy |
LinkingTo: | Rcpp |
Suggests: | knitr, rmarkdown, ggplot2, dplyr, tidyr, reshape2, bodenmiller, abind |
Published: | 2019-11-11 |
DOI: | 10.32614/CRAN.package.hilbertSimilarity |
Author: | Yann Abraham [aut, cre], Marilisa Neri [aut], John Skilling [ctb] |
Maintainer: | Yann Abraham <yann.abraham at gmail.com> |
BugReports: | http://github.com/yannabraham/hilbertSimilarity/issues |
License: | CC BY-NC-SA 4.0 |
URL: | http://github.com/yannabraham/hilbertSimilarity |
NeedsCompilation: | yes |
Materials: | README |
CRAN checks: | hilbertSimilarity results |
Reference manual: | hilbertSimilarity.pdf |
Vignettes: |
Comparing Samples using hilbertSimilarity Identifying Treatment effects using hilbertSimilarity |
Package source: | hilbertSimilarity_0.4.3.tar.gz |
Windows binaries: | r-devel: hilbertSimilarity_0.4.3.zip, r-release: hilbertSimilarity_0.4.3.zip, r-oldrel: hilbertSimilarity_0.4.3.zip |
macOS binaries: | r-release (arm64): hilbertSimilarity_0.4.3.tgz, r-oldrel (arm64): hilbertSimilarity_0.4.3.tgz, r-release (x86_64): hilbertSimilarity_0.4.3.tgz, r-oldrel (x86_64): hilbertSimilarity_0.4.3.tgz |
Old sources: | hilbertSimilarity archive |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.