hlaR: Tools for HLA Data

A streamlined tool for eplet analysis of donor and recipient HLA (human leukocyte antigen) mismatch. Messy, low-resolution HLA typing data is cleaned, and imputed to high-resolution using the NMDP (National Marrow Donor Program) haplotype reference database <https://haplostats.org/haplostats>. High resolution data is analyzed for overall or single antigen eplet mismatch using a reference table (currently supporting 'HLAMatchMaker' <http://www.epitopes.net> versions 2 and 3). Data can enter or exit the workflow at different points depending on the user's aims and initial data quality.

Version:	1.0.0
Depends:	R (≥ 4.1.0)
Imports:	devtools, tidyverse, dplyr, reshape2, schoolmath, tibble, tidyselect, stringr, purrr, tidyr, utils, readr, janitor
Suggests:	knitr, rmarkdown
Published:	2023-01-31
DOI:	10.32614/CRAN.package.hlaR
Author:	Joan Zhang [aut, cre], Aileen Johnson [aut], Christian P Larsen [cph, aut]
Maintainer:	Joan Zhang <joan.zhang at emory.edu>
BugReports:	https://github.com/LarsenLab/hlaR/issues
License:	MIT + file LICENSE
URL:	https://pubmed.ncbi.nlm.nih.gov/35101308/, https://emory-larsenlab.shinyapps.io/hlar_shiny/
NeedsCompilation:	no
CRAN checks:	hlaR results

Documentation:

Reference manual:	hlaR.pdf
Vignettes:	Imputation Eplet Mismatch

Downloads:

Package source:	hlaR_1.0.0.tar.gz
Windows binaries:	r-devel: hlaR_1.0.0.zip, r-release: hlaR_1.0.0.zip, r-oldrel: hlaR_1.0.0.zip
macOS binaries:	r-release (arm64): hlaR_1.0.0.tgz, r-oldrel (arm64): hlaR_1.0.0.tgz, r-release (x86_64): hlaR_1.0.0.tgz, r-oldrel (x86_64): hlaR_1.0.0.tgz
Old sources:	hlaR archive

Linking:

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