simFastBOIN: Fast Simulation of Bayesian Optimal Interval Designs for Phase I Trials

Design and evaluate phase I dose-finding trials that use the Bayesian optimal interval (BOIN) design of Liu and Yuan (2015) <doi:10.1111/rssc.12089>. Functions are provided to tabulate the decision boundaries, to simulate trials, to estimate the dose-toxicity curve under a monotonicity constraint and to select the maximum tolerated dose. The simulation engine is written in C++ and draws one random variate per patient in enrollment order, which reproduces the reference implementation in the 'BOIN' package trial by trial for a given seed. The traditional 3+3 design is provided as a comparator, with operating characteristics obtained in closed form rather than by simulation. For toxicity that is observed late, the time-to-event BOIN design is provided with the two estimators of Yuan and colleagues (2018) <doi:10.1158/1078-0432.CCR-18-0246> and Lin and Yuan (2020) <doi:10.1093/biostatistics/kxz007>. Patients who arrive while the dose escalation waits can be backfilled to lower doses with the designs of Zhao and colleagues (2024) <doi:10.1158/1078-0432.CCR-23-2585> and Chen and colleagues (2026) <doi:10.1007/s43441-026-00994-0>, the latter with the suspension rules of Chen and colleagues (2025) <doi:10.1158/1078-0432.CCR-24-3669>. Trials of two drugs given together are handled by the drug-combination design of Lin and Yin (2017) <doi:10.1177/0962280215594494>.

Version:	2.1.0
Depends:	R (≥ 3.5.0)
Imports:	Iso, Rcpp (≥ 1.0.0), stats, utils
LinkingTo:	Rcpp
Suggests:	BOIN, ggplot2 (≥ 3.4.0), knitr, rmarkdown, spelling, testthat (≥ 3.0.0)
Published:	2026-10-16
DOI:	10.32614/CRAN.package.simFastBOIN
Author:	Gosuke Homma [aut, cre]
Maintainer:	Gosuke Homma <my.name.is.gosuke at gmail.com>
BugReports:	https://github.com/gosukehommaEX/simFastBOIN/issues
License:	MIT + file LICENSE
URL:	https://gosukehommaex.github.io/simFastBOIN/, https://github.com/gosukehommaEX/simFastBOIN
NeedsCompilation:	yes
Language:	en-US
Materials:	README, NEWS
CRAN checks:	simFastBOIN results

Documentation:

Reference manual:	simFastBOIN.html , simFastBOIN.pdf
Vignettes:	Backfilling with the BF-BOIN and BE-BOIN designs (source, R code) Drug-combination trials with the BOIN design (source, R code) Getting started with simFastBOIN (source, R code) Late-onset toxicity with the TITE-BOIN design (source, R code)

Downloads:

Package source:	simFastBOIN_2.1.0.tar.gz
Windows binaries:	r-devel: simFastBOIN_2.1.0.zip, r-release: simFastBOIN_2.1.0.zip, r-oldrel: simFastBOIN_2.1.0.zip
macOS binaries:	r-release (arm64): simFastBOIN_2.1.0.tgz, r-oldrel (arm64): simFastBOIN_2.1.0.tgz, r-release (x86_64): simFastBOIN_2.1.0.tgz, r-oldrel (x86_64): simFastBOIN_2.1.0.tgz
Old sources:	simFastBOIN archive

Linking:

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