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simIDM: Simulating Oncology Trials using an Illness-Death Model

Based on the illness-death model a large number of clinical trials with oncology endpoints progression-free survival (PFS) and overall survival (OS) can be simulated, see Meller, Beyersmann and Rufibach (2019) <doi:10.1002/sim.8295>. The simulation set-up allows for random and event-driven censoring, an arbitrary number of treatment arms, staggered study entry and drop-out. Exponentially, Weibull and piecewise exponentially distributed survival times can be generated. The correlation between PFS and OS can be calculated.

Version: 0.1.0
Depends: R (≥ 3.6)
Imports: checkmate, furrr, future, mstate, parallelly, stats, survival
Suggests: coxphw, knitr, mvna, prodlim, rmarkdown, rpact, testthat (≥ 3.0.0)
Published: 2023-12-11
DOI: 10.32614/CRAN.package.simIDM
Author: Alexandra Erdmann [aut, cre], Kaspar Rufibach [aut], Holger Löwe [aut], Daniel Sabanés Bové [aut], F. Hoffmann-La Roche AG [cph, fnd], University of Ulm [cph, fnd]
Maintainer: Alexandra Erdmann <alexandra.erdmann at uni-ulm.de>
BugReports: https://github.com/insightsengineering/simIDM/issues
License: Apache License 2.0
URL: https://github.com/insightsengineering/simIDM/
NeedsCompilation: no
Language: en-US
Materials: NEWS
CRAN checks: simIDM results

Documentation:

Reference manual: simIDM.pdf
Vignettes: Correlation between PFS and OS
Piecewise Constant Hazards Calculations
Getting Started
Power and Type I Error Calculations

Downloads:

Package source: simIDM_0.1.0.tar.gz
Windows binaries: r-devel: simIDM_0.1.0.zip, r-release: simIDM_0.1.0.zip, r-oldrel: simIDM_0.1.0.zip
macOS binaries: r-release (arm64): simIDM_0.1.0.tgz, r-oldrel (arm64): simIDM_0.1.0.tgz, r-release (x86_64): simIDM_0.1.0.tgz, r-oldrel (x86_64): simIDM_0.1.0.tgz
Old sources: simIDM archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=simIDM to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.