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sumFREGAT: Fast Region-Based Association Tests on Summary Statistics

An adaptation of classical region/gene-based association analysis techniques to the use of summary statistics (P values and effect sizes) and correlations between genetic variants as input. It is a tool to perform the most popular and efficient gene-based tests using the results of genome-wide association (meta-)analyses without having the original genotypes and phenotypes at hand. See for details: Svishcheva et al (2019) Gene-based association tests using GWAS summary statistics. Bioinformatics. Belonogova et al (2022) SumSTAAR: A flexible framework for gene-based association studies using GWAS summary statistics. PLOS Comp Biol.

Version: 1.2.5
Depends: R (≥ 3.0.0)
Imports: methods, Matrix, splines, seqminer, GBJ
Suggests: data.table
Published: 2022-06-07
DOI: 10.32614/CRAN.package.sumFREGAT
Author: Nadezhda M. Belonogova and Gulnara R. Svishcheva with contributions from: Seunggeun Lee (kernel functions), Pierre Lafaye de Micheaux ('davies' method), Thomas Lumley ('kuonen' method), Minghui Wang, Yiyuan Liu, Shizhong Han (simpleM function), Yaowu Liu (ACAT function), James O. Ramsay (functional data analysis functions), Xihao Li, Zilin Li, and Han Chen (conception of the STAAR procedure)
Maintainer: Nadezhda M. Belonogova <belon at bionet.nsc.ru>
License: GPL-3
NeedsCompilation: yes
Materials: ChangeLog
CRAN checks: sumFREGAT results

Documentation:

Reference manual: sumFREGAT.pdf

Downloads:

Package source: sumFREGAT_1.2.5.tar.gz
Windows binaries: r-devel: sumFREGAT_1.2.5.zip, r-release: sumFREGAT_1.2.5.zip, r-oldrel: sumFREGAT_1.2.5.zip
macOS binaries: r-release (arm64): sumFREGAT_1.2.5.tgz, r-oldrel (arm64): sumFREGAT_1.2.5.tgz, r-release (x86_64): sumFREGAT_1.2.5.tgz, r-oldrel (x86_64): sumFREGAT_1.2.5.tgz
Old sources: sumFREGAT archive

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.