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Phase I clinical trials are the first step in drug development to test a new drug or drug combination on humans. Typical designs of Phase I trials use toxicity as the primary endpoint and aim to find the maximum tolerable dosage. However, these designs are poorly applicable for the development of cancer therapeutic vaccines because the expected safety concerns for these vaccines are not as much as cytotoxic agents. The primary objectives of a cancer therapeutic vaccine phase I trial thus often include determining whether the vaccine shows biologic activity and the minimum dose necessary to achieve a full immune or even clinical response. This package implements a Bayesian Phase I cancer vaccine trial design that allows simultaneous evaluation of safety and immunogenicity outcomes. See Wang et al. (2019) <doi:10.1002/sim.8021> for further details.
| Version: | 2.2 |
| Depends: | methods, R (≥ 3.5.0), rstan (≥ 2.19.2), Rcpp (≥ 1.0.2) |
| Imports: | sqldf (≥ 0.4), parallel (≥ 3.2), rstantools (≥ 2.1.1), RcppParallel (≥ 5.0.2) |
| LinkingTo: | BH (≥ 1.69.0-1), Rcpp (≥ 1.0.2), rstan (≥ 2.14), RcppEigen (≥ 0.3.3.5.0), StanHeaders (≥ 2.18.1-10), RcppParallel (≥ 5.0.2) |
| Suggests: | knitr, shiny, rmarkdown, pander, xtable |
| Published: | 2023-08-09 |
| DOI: | 10.32614/CRAN.package.visit |
| Author: | Zilu Wang [aut, cre] Chenguang Wang [aut, cre] Gary L Rosner [aut] Richard BS Roden [aut] Trustees of Columbia University [cph] (tools/make_cpp.R, R/stanmodels.R) |
| Maintainer: | Chenguang Wang <cwang68 at jhmi.edu> |
| License: | GPL (≥ 3) |
| NeedsCompilation: | yes |
| SystemRequirements: | GNU make |
| CRAN checks: | visit results |
| Reference manual: | visit.pdf |
| Vignettes: |
visit: Vaccine Phase I Design with Simultaneous Evaluation of Immnunogeneicity and Toxicity |
| Package source: | visit_2.2.tar.gz |
| Windows binaries: | r-devel: visit_2.2.zip, r-release: visit_2.2.zip, r-oldrel: visit_2.2.zip |
| macOS binaries: | r-release (arm64): visit_2.2.tgz, r-oldrel (arm64): visit_2.2.tgz, r-release (x86_64): visit_2.2.tgz, r-oldrel (x86_64): visit_2.2.tgz |
| Old sources: | visit archive |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.