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ASSISTant: Adaptive Subgroup Selection in Group Sequential Trials

Clinical trial design for subgroup selection in three-stage group sequential trial as described in Lai, Lavori and Liao (2014, <doi:10.1016/j.cct.2014.09.001>). Includes facilities for design, exploration and analysis of such trials. An implementation of the initial DEFUSE-3 trial is also provided as a vignette.

Version: 1.4.3
Imports: R6, mvtnorm, knitr, magrittr, dplyr
Suggests: rmarkdown
Published: 2022-12-02
DOI: 10.32614/CRAN.package.ASSISTant
Author: Tze Leung Lai [ctb], Philip Lavori [aut], Olivia Liao [aut], Balasubramanian Narasimhan [aut, cre], Ka Wai Tsang [aut]
Maintainer: Balasubramanian Narasimhan <naras at stat.Stanford.EDU>
BugReports: https://github.com/bnaras/ASSISTant/issues
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
URL: https://github.com/bnaras/ASSISTant
NeedsCompilation: no
Materials: README NEWS
CRAN checks: ASSISTant results

Documentation:

Reference manual: ASSISTant.pdf
Vignettes: Adaptive Subgroup Selection in Sequential Trials
Design of the DEFUSE3 Trial
Using Discrete Rankin Scores

Downloads:

Package source: ASSISTant_1.4.3.tar.gz
Windows binaries: r-devel: ASSISTant_1.4.3.zip, r-release: ASSISTant_1.4.3.zip, r-oldrel: ASSISTant_1.4.3.zip
macOS binaries: r-release (arm64): ASSISTant_1.4.3.tgz, r-oldrel (arm64): ASSISTant_1.4.3.tgz, r-release (x86_64): ASSISTant_1.4.3.tgz, r-oldrel (x86_64): ASSISTant_1.4.3.tgz
Old sources: ASSISTant archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=ASSISTant to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.