Certara.NLME8: Utilities for Certara's Nonlinear Mixed-Effects Modeling Engine

Interface to Certara's Nonlinear Mixed-Effects (NLME) modeling engine ('NLME-Engine') for pharmacokinetic and pharmacodynamic (PK/PD) modeling and simulation. Provides access to the Maximum Likelihood estimation algorithms available in the 'Phoenix' NLME platform for population, individual, and pooled analyses using parametric methods. Includes utilities for setting up NLME installations and parallel settings, running estimation, bootstrap, and covariate search workflows, and updating model files from engine output. Jobs can be executed locally or across high-performance computing resources, including Linux Sun Grid Engine (SGE) and Simple Linux Utility for Resource Management (SLURM) grids as well as multicore Linux and Windows hosts.

Version:	3.2.0
Depends:	R (≥ 4.0.0)
Imports:	xml2, batchtools (≥ 0.9.9), utils, data.table
Suggests:	testthat, brew, withr
Published:	2026-09-11
DOI:	10.32614/CRAN.package.Certara.NLME8
Author:	Soltanshahi Fred [aut], Michael Tomashevskiy [aut], James Craig [aut, cre], Shuhua Hu [ctb], Certara USA, Inc. [cph, fnd]
Maintainer:	James Craig <james.craig at certara.com>
License:	LGPL-3
NeedsCompilation:	no
Materials:	README
CRAN checks:	Certara.NLME8 results

Documentation:

Reference manual:

Certara.NLME8.html , Certara.NLME8.pdf

Downloads:

Package source:	Certara.NLME8_3.2.0.tar.gz
Windows binaries:	r-devel: Certara.NLME8_3.2.0.zip, r-release: Certara.NLME8_3.2.0.zip, r-oldrel: Certara.NLME8_3.2.0.zip
macOS binaries:	r-release (arm64): Certara.NLME8_3.0.2.tgz, r-oldrel (arm64): Certara.NLME8_3.2.0.tgz, r-release (x86_64): Certara.NLME8_3.2.0.tgz, r-oldrel (x86_64): Certara.NLME8_3.2.0.tgz
Old sources:	Certara.NLME8 archive

Reverse dependencies:

Reverse imports:

Certara.RsNLME, Certara.RsNLME.ModelExecutor

Linking:

Please use the canonical form https://CRAN.R-project.org/package=Certara.NLME8 to link to this page.