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DRviaSPCN: Drug Repurposing in Cancer via a Subpathway Crosstalk Network

A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.

Version: 0.1.4
Depends: R (≥ 3.6)
Imports: GSVA, clusterProfiler, graphics, igraph, pheatmap, stats, sp, ChemmineR
Suggests: rmarkdown, knitr, DT
Published: 2024-01-13
DOI: 10.32614/CRAN.package.DRviaSPCN
Author: Junwei Han [aut, cre, cph], Jiashuo Wu [aut]
Maintainer: Junwei Han <hanjunwei1981 at 163.com>
License: GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation: no
CRAN checks: DRviaSPCN results

Documentation:

Reference manual: DRviaSPCN.pdf
Vignettes: DRviaSPCN

Downloads:

Package source: DRviaSPCN_0.1.4.tar.gz
Windows binaries: r-devel: DRviaSPCN_0.1.4.zip, r-release: DRviaSPCN_0.1.4.zip, r-oldrel: DRviaSPCN_0.1.4.zip
macOS binaries: r-release (arm64): DRviaSPCN_0.1.4.tgz, r-oldrel (arm64): not available, r-release (x86_64): DRviaSPCN_0.1.4.tgz, r-oldrel (x86_64): not available
Old sources: DRviaSPCN archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=DRviaSPCN to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.