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A systematic biology tool was developed to repurpose drugs via a subpathway crosstalk network. The operation modes include 1) calculating centrality scores of SPs in the context of gene expression data to reflect the influence of SP crosstalk, 2) evaluating drug-disease reverse association based on disease- and drug-induced SPs weighted by the SP crosstalk, 3) identifying cancer candidate drugs through perturbation analysis. There are also several functions used to visualize the results.
| Version: | 0.1.4 |
| Depends: | R (≥ 3.6) |
| Imports: | GSVA, clusterProfiler, graphics, igraph, pheatmap, stats, sp, ChemmineR |
| Suggests: | rmarkdown, knitr, DT |
| Published: | 2024-01-13 |
| DOI: | 10.32614/CRAN.package.DRviaSPCN |
| Author: | Junwei Han [aut, cre, cph], Jiashuo Wu [aut] |
| Maintainer: | Junwei Han <hanjunwei1981 at 163.com> |
| License: | GPL-2 | GPL-3 [expanded from: GPL (≥ 2)] |
| NeedsCompilation: | no |
| CRAN checks: | DRviaSPCN results [issues need fixing before 2025-01-12] |
| Reference manual: | DRviaSPCN.pdf |
| Vignettes: |
DRviaSPCN |
| Package source: | DRviaSPCN_0.1.4.tar.gz |
| Windows binaries: | r-devel: DRviaSPCN_0.1.4.zip, r-release: DRviaSPCN_0.1.4.zip, r-oldrel: DRviaSPCN_0.1.4.zip |
| macOS binaries: | r-release (arm64): DRviaSPCN_0.1.4.tgz, r-oldrel (arm64): not available, r-release (x86_64): DRviaSPCN_0.1.4.tgz, r-oldrel (x86_64): not available |
| Old sources: | DRviaSPCN archive |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.