EpiSemble: Ensemble Based Machine Learning Approach for Predicting Methylation States

DNA methylation (6mA) is a major epigenetic process by which alteration in gene expression took place without changing the DNA sequence. Predicting these sites in-vitro is laborious, time consuming as well as costly. This 'EpiSemble' package is an in-silico pipeline for predicting DNA sequences containing the 6mA sites. It uses an ensemble-based machine learning approach by combining Support Vector Machine (SVM), Random Forest (RF) and Gradient Boosting approach to predict the sequences with 6mA sites in it. This package has been developed by using the concept of Chen et al. (2019) <doi:10.1093/bioinformatics/btz015>.

Version:	0.1.1
Imports:	stats, devtools, tidyverse, seqinr, Biostrings, splitstackshape, entropy, party, stringr, tibble, doParallel, parallel, e1071, caret, randomForest, gbm, foreach, ftrCOOL, iterators
Published:	2023-06-04
DOI:	10.32614/CRAN.package.EpiSemble
Author:	Dipro Sinha [aut, cre], Sunil Archak [aut], Dwijesh Chandra Mishra [aut], Tanwy Dasmandal [aut], Md Yeasin [aut]
Maintainer:	Dipro Sinha <diprosinha at gmail.com>
License:	GPL-3
NeedsCompilation:	no
CRAN checks:	EpiSemble results

Documentation:

Reference manual:

EpiSemble.pdf

Downloads:

Package source:	EpiSemble_0.1.1.tar.gz
Windows binaries:	r-devel: EpiSemble_0.1.1.zip, r-release: EpiSemble_0.1.1.zip, r-oldrel: EpiSemble_0.1.1.zip
macOS binaries:	r-release (arm64): EpiSemble_0.1.1.tgz, r-oldrel (arm64): EpiSemble_0.1.1.tgz, r-release (x86_64): EpiSemble_0.1.1.tgz, r-oldrel (x86_64): EpiSemble_0.1.1.tgz
Old sources:	EpiSemble archive

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