GRIN2: Genomic Random Interval (GRIN)

Implements the Genomic Random Interval (GRIN) framework for identifying genomic loci affected by genomic lesions more frequently than expected by chance. Supports multiple lesion classes, lesion constellation analysis, exon-level target-size modeling, genomic lesion visualization, and gene-level association analyses linking genomic lesions or gene expression with binary and time-to-event clinical outcomes. Includes tools for retrieving versioned GRCh38 Ensembl gene, exon, and regulatory-element annotations. The statistical framework is described in Pounds et al. (2013) <doi:10.1093/bioinformatics/btt372>.

Version:	2.1.0
Depends:	R (≥ 4.2.0)
Imports:	circlize, data.table, dplyr, forcats, ggplot2, graphics, grDevices, grid, magrittr, stats, survival, tibble, tools, utils, writexl
Suggests:	AnnotationHub, biomaRt, ComplexHeatmap, ensembldb, GenomeInfoDb, GenomicRanges, gridExtra, gridGraphics, Gviz, IRanges, knitr, rmarkdown, S4Vectors
Published:	2026-08-22
DOI:	10.32614/CRAN.package.GRIN2
Author:	Abdelrahman Elsayed [aut, cre, cph], Xueyuan Cao [aut], Lakshmi Anuhya Patibandla [aut], Stanley Pounds [aut, cph]
Maintainer:	Abdelrahman Elsayed <aelsayed at stjude.org>
BugReports:	https://github.com/abdel-elsayed87/GRIN2/issues
License:	GPL (≥ 3)
URL:	https://github.com/abdel-elsayed87/GRIN2
NeedsCompilation:	no
Materials:	NEWS
CRAN checks:	GRIN2 results

Documentation:

Reference manual:	GRIN2.html , GRIN2.pdf
Vignettes:	GRIN2: Genomic Random Interval Analysis (source, R code)

Downloads:

Package source:	GRIN2_2.1.0.tar.gz
Windows binaries:	r-devel: GRIN2_2.1.0.zip, r-release: GRIN2_2.1.0.zip, r-oldrel: GRIN2_2.1.0.zip
macOS binaries:	r-release (arm64): GRIN2_2.1.0.tgz, r-oldrel (arm64): GRIN2_2.1.0.tgz, r-release (x86_64): GRIN2_2.1.0.tgz, r-oldrel (x86_64): GRIN2_2.1.0.tgz
Old sources:	GRIN2 archive

Linking:

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