The hardware and bandwidth for this mirror is donated by METANET, the Webhosting and Full Service-Cloud Provider.
If you wish to report a bug, or if you are interested in having us mirror your free-software or open-source project, please feel free to contact us at mirror[@]metanet.ch.

PFIM: Population Fisher Information Matrix

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix; see <doi:10.1093/biomet/84.2.429> and <doi:10.1016/S0169-2607(00)00117-6>. Supports population, individual, and Bayesian 'FIMs', covariates, inter-occasion variability, and D-optimal search ('Fedorov-Wynn', multiplicative, simplex, 'PSO', 'PGBO').

Version:	8.0.1
Depends:	R (≥ 4.5.0)
Imports:	utils, Deriv, Rcpp, methods, deSolve, purrr, stringr, S7 (≥ 0.2.0), Matrix, ggplot2 (≥ 3.5.0), kableExtra, tibble, scales, stats, rmarkdown, rlang, knitr, tools, grDevices
LinkingTo:	Rcpp, RcppArmadillo
Suggests:	testthat (≥ 3.2.3), withr
Published:	2026-10-16
DOI:	10.32614/CRAN.package.PFIM
Author:	Romain Leroux [aut], France Mentré [cre], Lucie Fayette [ctb], Antoine Croxo [ctb], Jérémy Seurat [ctb]
Maintainer:	France Mentré <pfim at inserm.fr>
BugReports:	https://github.com/iame-researchCenter/PFIM/issues
License:	GPL-3
URL:	https://github.com/iame-researchCenter/PFIM
NeedsCompilation:	yes
Citation:	PFIM citation info
Materials:	NEWS
In views:	Pharmacokinetics
CRAN checks:	PFIM results

Documentation:

Reference manual:	PFIM.html , PFIM.pdf
Vignettes:	Library of models (source, R code) Design evaluation and optimization in discrete space (source, R code) Design evaluation and optimization in continuous space (source, R code) Design evaluation and optimization with covariates — analytical PK model (source, R code) Optimizing a Sparse PK Design in Pediatric Patients (source, R code) G-CSF PK-PD design evaluation (source, R code)

Downloads:

Package source:	PFIM_8.0.1.tar.gz
Windows binaries:	r-devel: PFIM_8.0.1.zip, r-release: PFIM_8.0.1.zip, r-oldrel: PFIM_8.0.1.zip
macOS binaries:	r-release (arm64): PFIM_8.0.1.tgz, r-oldrel (arm64): PFIM_8.0.1.tgz, r-release (x86_64): PFIM_8.0.1.tgz, r-oldrel (x86_64): PFIM_8.0.1.tgz
Old sources:	PFIM archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=PFIM to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.