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PFIM: Population Fisher Information Matrix

Evaluate or optimize designs for nonlinear mixed effects models using the Fisher Information matrix. Supports population, individual, and Bayesian 'FIMs', covariates, inter-occasion variability, and D-optimal search ('Fedorov-Wynn', multiplicative, simplex, 'PSO', 'PGBO').

Version: 8.0
Depends: R (≥ 4.5.0)
Imports: utils, Deriv, methods, deSolve, purrr, stringr, S7 (≥ 0.2.0), Matrix, ggplot2 (≥ 3.5.0), Rcpp, kableExtra, tibble, scales, stats, rmarkdown, rlang, knitr, tools, grDevices
LinkingTo: Rcpp, RcppArmadillo
Suggests: testthat (≥ 3.2.3), withr
Published: 2026-09-28
DOI: 10.32614/CRAN.package.PFIM
Author: Romain Leroux ORCID iD [aut], France Mentré ORCID iD [cre], Antoine Croxo ORCID iD [ctb], Jérémy Seurat [ctb]
Maintainer: France Mentré <pfim at inserm.fr>
License: GPL-3 | file LICENSE
URL: http://www.pfim.biostat.fr/
NeedsCompilation: yes
SystemRequirements: C++17
Citation: PFIM citation info
Materials: NEWS
In views: Pharmacokinetics
CRAN checks: PFIM results [issues need fixing before 2026-10-20]

Documentation:

Reference manual: PFIM.html , PFIM.pdf
Vignettes: Design evaluation and optimization in discrete space (source, R code)
Design evaluation and optimization in continuous space (source, R code)
Design evaluation and optimization with covariates — analytical PK model (source, R code)
G-CSF PK-PD design evaluation (source, R code)
Library of models (source, R code)

Downloads:

Package source: PFIM_8.0.tar.gz
Windows binaries: r-devel: PFIM_8.0.zip, r-release: PFIM_8.0.zip, r-oldrel: PFIM_8.0.zip
macOS binaries: r-release (arm64): PFIM_7.0.3.tgz, r-oldrel (arm64): PFIM_7.0.3.tgz, r-release (x86_64): PFIM_8.0.tgz, r-oldrel (x86_64): PFIM_8.0.tgz
Old sources: PFIM archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=PFIM to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.