PWEALL: Design and Monitoring of Survival Trials Accounting for Complex Situations

Calculates various functions needed for design and monitoring survival trials accounting for complex situations such as delayed treatment effect, treatment crossover, non-uniform accrual, and different censoring distributions between groups. The event time distribution is assumed to be piecewise exponential (PWE) distribution and the entry time is assumed to be piecewise uniform distribution. As compared with Version 1.2.1, two more types of hybrid crossover are added. A bug is corrected in the function "pwecx" that calculates the crossover-adjusted survival, distribution, density, hazard and cumulative hazard functions. Also, to generate the crossover-adjusted event time random variable, a more efficient algorithm is used and the output includes crossover indicators.

Version:	1.3.0.1
Depends:	R (≥ 3.1.2)
Imports:	survival, stats
Published:	2023-08-09
DOI:	10.32614/CRAN.package.PWEALL
Author:	Xiaodong Luo [aut, cre], Xuezhou Mao [ctb], Xun Chen [ctb], Hui Quan [ctb], Sanofi [cph]
Maintainer:	Xiaodong Luo <Xiaodong.Luo at sanofi.com>
License:	GPL-2 | GPL-3 [expanded from: GPL (≥ 2)]
NeedsCompilation:	yes
CRAN checks:	PWEALL results

Documentation:

Reference manual:

PWEALL.pdf

Downloads:

Package source:	PWEALL_1.3.0.1.tar.gz
Windows binaries:	r-devel: PWEALL_1.3.0.1.zip, r-release: PWEALL_1.3.0.1.zip, r-oldrel: PWEALL_1.3.0.1.zip
macOS binaries:	r-release (arm64): PWEALL_1.3.0.1.tgz, r-oldrel (arm64): PWEALL_1.3.0.1.tgz, r-release (x86_64): PWEALL_1.3.0.1.tgz, r-oldrel (x86_64): PWEALL_1.3.0.1.tgz
Old sources:	PWEALL archive

Reverse dependencies:

Reverse imports:

NBDesign

Linking:

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