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TrialEmulation: Causal Analysis of Observational Time-to-Event Data

Implements target trial emulation methods to apply randomized clinical trial design and analysis in an observational setting. Using marginal structural models, it can estimate intention-to-treat and per-protocol effects in emulated trials using electronic health records. A description and application of the method can be found in Danaei et al (2013) <doi:10.1177/0962280211403603>.

Version: 0.0.4.0
Depends: R (≥ 4.0.0)
Imports: broom (≥ 0.7.10), checkmate, data.table (≥ 1.9.8), DBI, duckdb, formula.tools, lifecycle, lmtest, methods, mvtnorm, parglm, Rcpp, sandwich
LinkingTo: Rcpp
Suggests: knitr, parsnip, rmarkdown, rpart, testthat (≥ 3.0.0), withr
Published: 2024-11-29
DOI: 10.32614/CRAN.package.TrialEmulation
Author: Isaac Gravestock ORCID iD [aut, cre], Li Su [aut], Roonak Rezvani ORCID iD [aut] (Original package author), Julia Moesch [aut], Medical Research Council (MRC) [fnd], F. Hoffmann-La Roche AG [cph, fnd]
Maintainer: Isaac Gravestock <isaac.gravestock at roche.com>
BugReports: https://github.com/Causal-LDA/TrialEmulation/issues
License: Apache License (≥ 2)
URL: https://causal-lda.github.io/TrialEmulation/, https://github.com/Causal-LDA/TrialEmulation
NeedsCompilation: yes
Language: en-GB
Materials: README NEWS
CRAN checks: TrialEmulation results

Documentation:

Reference manual: TrialEmulation.pdf
Vignettes: Extending-TrialEmulation (source, R code)
Getting-Started (source, R code)
New Interface (source, R code)

Downloads:

Package source: TrialEmulation_0.0.4.0.tar.gz
Windows binaries: r-devel: TrialEmulation_0.0.4.0.zip, r-release: TrialEmulation_0.0.4.0.zip, r-oldrel: TrialEmulation_0.0.4.0.zip
macOS binaries: r-release (arm64): TrialEmulation_0.0.4.0.tgz, r-oldrel (arm64): TrialEmulation_0.0.4.0.tgz, r-release (x86_64): TrialEmulation_0.0.4.0.tgz, r-oldrel (x86_64): TrialEmulation_0.0.4.0.tgz
Old sources: TrialEmulation archive

Linking:

Please use the canonical form https://CRAN.R-project.org/package=TrialEmulation to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.