detectPanel: Leakage-Aware Discovery of Small Biomarker Panels

Discovers small binary-classification biomarker panels from count or expression matrices while prioritizing detectability, expression stability, and univariate discrimination. Candidate filtering and panel selection can be repeated inside nested cross-validation to reduce information leakage. The package provides shared resampling splits, exhaustive small-panel search, logistic model fitting with an automatic ridge fallback for unstable separation-prone fits, out-of-fold evaluation, selection-frequency summaries, and optional 'DESeq2' differential-expression support. The nested model-selection workflow follows Varma and Simon (2006) <doi:10.1186/1471-2105-7-91>, and the optional differential-expression analysis uses Love, Huber, and Anders (2014) <doi:10.1186/s13059-014-0550-8>.

Version:	0.1.3
Depends:	R (≥ 4.2.0)
Imports:	ggplot2, graphics, stats, utils
Suggests:	DESeq2, knitr, rmarkdown, pheatmap, testthat (≥ 3.0.0)
Published:	2026-09-15
DOI:	10.32614/CRAN.package.detectPanel (may not be active yet)
Author:	Fuhao Jiang [aut, cre]
Maintainer:	Fuhao Jiang <emr39515 at gmail.com>
BugReports:	https://github.com/Emr-27/detectPanel/issues
License:	MIT + file LICENSE
URL:	https://github.com/Emr-27/detectPanel
NeedsCompilation:	no
Citation:	detectPanel citation info
Materials:	README, NEWS
CRAN checks:	detectPanel results

Documentation:

Reference manual:	detectPanel.html , detectPanel.pdf
Vignettes:	Leakage-aware biomarker panel discovery (source, R code)

Downloads:

Package source:	detectPanel_0.1.3.tar.gz
Windows binaries:	r-devel: not available, r-release: detectPanel_0.1.3.zip, r-oldrel: detectPanel_0.1.3.zip
macOS binaries:	r-release (arm64): not available, r-oldrel (arm64): detectPanel_0.1.3.tgz, r-release (x86_64): detectPanel_0.1.3.tgz, r-oldrel (x86_64): detectPanel_0.1.3.tgz

Linking:

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