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Provides a comprehensive set of tools to simulate, evaluate, and compare model-assisted designs for early-phase (Phase I/II) clinical trials, including: - BOIN12 (Bayesian optimal interval phase 1/11 trial design; Lin et al. (2020) <doi:10.1200/PO.20.00257>), - BOIN-ET (Takeda, K., Taguri, M., & Morita, S. (2018) <doi:10.1002/pst.1864>), - EffTox (Thall, P. F., & Cook, J. D. (2004) <doi:10.1111/j.0006-341X.2004.00218.x>), - Ji3+3 (Joint i3+3 design; Lin, X., & Ji, Y. (2020) <doi:10.1080/10543406.2020.1818250>), - PRINTE (probability intervals of toxicity and efficacy design; Lin, X., & Ji, Y. (2021) <doi:10.1177/0962280220977009>), - STEIN (simple toxicity and efficacy interval design; Lin, R., & Yin, G. (2017) <doi:10.1002/sim.7428>), - TEPI (toxicity and efficacy probability interval design; Li, D. H., Whitmore, J. B., Guo, W., & Ji, Y. (2017) <doi:10.1158/1078-0432.CCR-16-1125>), - uTPI (utility-based toxicity Probability interval design; Shi, H., Lin, R., & Lin, X. (2024) <doi:10.1002/sim.8922>). Includes flexible simulation parameters that allow researchers to efficiently compute operating characteristics under various fixed and random trial scenarios and export the results.
| Version: | 0.3.1 |
| Imports: | trialr, Iso |
| Suggests: | knitr, rmarkdown |
| Published: | 2025-09-02 |
| DOI: | 10.32614/CRAN.package.phase12designs |
| Author: | Angela Cao [aut, cre], Haolun Shi [ctb] |
| Maintainer: | Angela Cao <cao.t.angela at gmail.com> |
| License: | MIT + file LICENSE |
| NeedsCompilation: | no |
| CRAN checks: | phase12designs results |
| Reference manual: | phase12designs.html , phase12designs.pdf |
| Vignettes: |
Getting Started (source, R code) |
| Package source: | phase12designs_0.3.1.tar.gz |
| Windows binaries: | r-devel: phase12designs_0.3.1.zip, r-release: phase12designs_0.3.1.zip, r-oldrel: phase12designs_0.3.1.zip |
| macOS binaries: | r-release (arm64): phase12designs_0.3.1.tgz, r-oldrel (arm64): phase12designs_0.3.1.tgz, r-release (x86_64): phase12designs_0.3.1.tgz, r-oldrel (x86_64): phase12designs_0.3.1.tgz |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.