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A collection of clinical trial designs and methods, implemented in 'rstan' and R, including: the Continual Reassessment Method by O'Quigley et al. (1990) <doi:10.2307/2531628>; EffTox by Thall & Cook (2004) <doi:10.1111/j.0006-341X.2004.00218.x>; the two-parameter logistic method of Neuenschwander, Branson & Sponer (2008) <doi:10.1002/sim.3230>; and the Augmented Binary method by Wason & Seaman (2013) <doi:10.1002/sim.5867>; and more. We provide functions to aid model-fitting and analysis. The 'rstan' implementations may also serve as a cookbook to anyone looking to extend or embellish these models. We hope that this package encourages the use of Bayesian methods in clinical trials. There is a preponderance of early phase trial designs because this is where Bayesian methods are used most. If there is a method you would like implemented, please get in touch.
Version: | 0.1.6 |
Depends: | R (≥ 3.5.0), methods, Rcpp (≥ 1.0.1) |
Imports: | rstan (≥ 2.18.2), rstantools (≥ 1.5.1), rlang (≥ 0.4.5), dplyr, purrr, magrittr, stringr, ggplot2, gtools, coda, tidybayes (≥ 2.0.3), tibble (≥ 3.0.0), binom, MASS |
LinkingTo: | StanHeaders (≥ 2.18.1), rstan (≥ 2.18.2), BH (≥ 1.69.0-1), Rcpp (≥ 1.0.1), RcppEigen (≥ 0.3.3.5.0), RcppParallel (≥ 5.0.2) |
Suggests: | testthat, knitr, rmarkdown, tidyr, ggridges, DiagrammeR |
Published: | 2023-03-12 |
DOI: | 10.32614/CRAN.package.trialr |
Author: | Kristian Brock [aut, cre], Trustees of Columbia University [cph] |
Maintainer: | Kristian Brock <kristian.brock at gmail.com> |
BugReports: | https://github.com/brockk/trialr/issues |
License: | GPL (≥ 3) |
URL: | https://github.com/brockk/trialr |
NeedsCompilation: | yes |
SystemRequirements: | GNU make |
Materials: | README NEWS |
CRAN checks: | trialr results |
Package source: | trialr_0.1.6.tar.gz |
Windows binaries: | r-devel: trialr_0.1.6.zip, r-release: trialr_0.1.6.zip, r-oldrel: trialr_0.1.6.zip |
macOS binaries: | r-release (arm64): trialr_0.1.6.tgz, r-oldrel (arm64): trialr_0.1.6.tgz, r-release (x86_64): trialr_0.1.6.tgz, r-oldrel (x86_64): trialr_0.1.6.tgz |
Old sources: | trialr archive |
Reverse imports: | brms.mmrm, escalation, historicalborrowlong |
Please use the canonical form https://CRAN.R-project.org/package=trialr to link to this page.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.