ssutil: Sample Size Calculation Tools

Functions for sample size estimation and simulation in clinical trials. Includes methods for selecting the best group using the Indifference-zone approach, as well as designs for non-inferiority, equivalence, and negative binomial models. For the sample size calculation for non-inferiority of vaccines, the approach is based on Fleming, Powers, and Huang (2021) <doi:10.1177/1740774520988244>. The Indifference-zone approach is based on Sobel and Huyett (1957) <doi:10.1002/j.1538-7305.1957.tb02411.x> and Bechhofer, Santner, and Goldsman (1995, ISBN:978-0-471-57427-9).

Version:	1.0.0
Depends:	R (≥ 4.1)
Imports:	stats, stringr, broom, MASS, gsDesign, mvtnorm, tibble
Suggests:	knitr, rmarkdown, spelling, testthat (≥ 3.0.0)
Published:	2025-06-12
DOI:	10.32614/CRAN.package.ssutil
Author:	John J. Aponte [aut, cre], Chris Gast [ctb]
Maintainer:	John J. Aponte <john.j.aponte at gmail.com>
BugReports:	https://github.com/johnaponte/ssutil/issues
License:	AGPL (≥ 3)
URL:	https://johnaponte.github.io/ssutil/, https://github.com/johnaponte/ssutil
NeedsCompilation:	no
Language:	en-US
Materials:	README NEWS
CRAN checks:	ssutil results

Documentation:

Reference manual:	ssutil.pdf
Vignettes:	Equivalence for Normal Outcomes (source, R code) Indifferent-Zone approach for binomial outcomes (source, R code) Indifferent-Zone approach for normal outcomes (source, R code) Negative Binomial outcomes (source, R code) Simulations for Non-inferiority trials (source, R code) Detectable Event Rate for Safety Signal Detection (source, R code)

Downloads:

Package source:	ssutil_1.0.0.tar.gz
Windows binaries:	r-devel: not available, r-release: not available, r-oldrel: ssutil_1.0.0.zip
macOS binaries:	r-release (arm64): ssutil_1.0.0.tgz, r-oldrel (arm64): ssutil_1.0.0.tgz, r-release (x86_64): not available, r-oldrel (x86_64): not available

Linking:

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