The hardware and bandwidth for this mirror is donated by METANET, the Webhosting and Full Service-Cloud Provider.
If you wish to report a bug, or if you are interested in having us mirror your free-software or open-source project, please feel free to contact us at mirror[@]metanet.ch.
A multiple-testing procedure for high-dimensional mediation hypotheses. Mediation analysis is of rising interest in epidemiology and clinical trials. Among existing methods for mediation analyses, the popular joint significance (JS) test yields an overly conservative type I error rate and therefore low power. In the R package 'HDMT' we implement a multiple-testing procedure that accurately controls the family-wise error rate (FWER) and the false discovery rate (FDR) when using JS for testing high-dimensional mediation hypotheses. The core of our procedure is based on estimating the proportions of three component null hypotheses and deriving the corresponding mixture distribution of null p-values. Results of the data examples include better-behaved quantile-quantile plots and improved detection of novel mediation relationships on the role of DNA methylation in genetic regulation of gene expression. With increasing interest in mediation by molecular intermediaries such as gene expression, the proposed method addresses an unmet methodological challenge. Methods used in the package refer to James Y. Dai, Janet L. Stanford & Michael LeBlanc (2020) <doi:10.1080/01621459.2020.1765785>.
| Version: | 1.0.5 |
| Depends: | R (≥ 3.4.0) |
| Imports: | fdrtool, qvalue |
| Suggests: | rmarkdown, knitr |
| Published: | 2022-01-29 |
| DOI: | 10.32614/CRAN.package.HDMT |
| Author: | James Dai [aut, cre], Xiaoyu Wang [aut] |
| Maintainer: | James Dai <jdai at fredhutch.org> |
| License: | MIT + file LICENSE |
| NeedsCompilation: | no |
| CRAN checks: | HDMT results |
| Reference manual: | HDMT.pdf |
| Vignettes: |
HDMT |
| Package source: | HDMT_1.0.5.tar.gz |
| Windows binaries: | r-devel: HDMT_1.0.5.zip, r-release: HDMT_1.0.5.zip, r-oldrel: HDMT_1.0.5.zip |
| macOS binaries: | r-release (arm64): HDMT_1.0.5.tgz, r-oldrel (arm64): HDMT_1.0.5.tgz, r-release (x86_64): HDMT_1.0.5.tgz, r-oldrel (x86_64): HDMT_1.0.5.tgz |
| Old sources: | HDMT archive |
| Reverse imports: | HIMA, medScan |
Please use the canonical form https://CRAN.R-project.org/package=HDMT to link to this page.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.