The hardware and bandwidth for this mirror is donated by METANET, the Webhosting and Full Service-Cloud Provider.
If you wish to report a bug, or if you are interested in having us mirror your free-software or open-source project, please feel free to contact us at mirror[@]metanet.ch.
Helps find meaningful patterns in complex genetic experiments. First gimap takes data from paired CRISPR (Clustered regularly interspaced short palindromic repeats) screens that has been pre-processed to counts table of paired gRNA (guide Ribonucleic Acid) reads. The input data will have cell counts for how well cells grow (or don't grow) when different genes or pairs of genes are disabled. The output of the 'gimap' package is genetic interaction scores which are the distance between the observed CRISPR score and the expected CRISPR score. The expected CRISPR scores are what we expect for the CRISPR values to be for two unrelated genes. The further away an observed CRISPR score is from its expected score the more we suspect genetic interaction. The work in this package is based off of original research from the Alice Berger lab at Fred Hutchinson Cancer Center (2021) <doi:10.1016/j.celrep.2021.109597>.
| Version: | 1.0.2 |
| Depends: | R (≥ 3.5.0) |
| Imports: | readr, dplyr, tidyr, rmarkdown, vroom, ggplot2, magrittr, pheatmap, purrr, janitor, broom, utils, stats, stringr, httr, jsonlite, openssl |
| Suggests: | testthat (≥ 3.0.0), roxygen2, kableExtra, knitr |
| Published: | 2025-02-18 |
| DOI: | 10.32614/CRAN.package.gimap |
| Author: | Candace Savonen [aut, cre], Phoebe Parrish [aut], Kate Isaac [aut], Howard Baek [aut], Daniel Grosso [aut], Siobhan O'Brien [aut], Alice Berger [aut] |
| Maintainer: | Candace Savonen <cansav09 at gmail.com> |
| BugReports: | https://github.com/FredHutch/gimap/issues |
| License: | GPL-3 |
| URL: | https://github.com/FredHutch/gimap |
| NeedsCompilation: | no |
| Materials: | README NEWS |
| CRAN checks: | gimap results |
| Reference manual: | gimap.pdf |
| Vignettes: |
Quick Start (source, R code) gimap for Timepoint Experiment (source, R code) gimap for Treatment Experiment (source, R code) |
| Package source: | gimap_1.0.2.tar.gz |
| Windows binaries: | r-devel: gimap_1.0.2.zip, r-release: gimap_1.0.2.zip, r-oldrel: gimap_1.0.2.zip |
| macOS binaries: | r-devel (arm64): gimap_1.0.1.tgz, r-release (arm64): gimap_1.0.1.tgz, r-oldrel (arm64): gimap_1.0.1.tgz, r-devel (x86_64): gimap_1.0.2.tgz, r-release (x86_64): gimap_1.0.2.tgz, r-oldrel (x86_64): gimap_1.0.2.tgz |
| Old sources: | gimap archive |
Please use the canonical form https://CRAN.R-project.org/package=gimap to link to this page.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.