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Fits the joint model proposed by Henderson and colleagues (2000) <doi:10.1093/biostatistics/1.4.465>, but extended to the case of multiple continuous longitudinal measures. The time-to-event data is modelled using a Cox proportional hazards regression model with time-varying covariates. The multiple longitudinal outcomes are modelled using a multivariate version of the Laird and Ware linear mixed model. The association is captured by a multivariate latent Gaussian process. The model is estimated using a Monte Carlo Expectation Maximization algorithm. This project was funded by the Medical Research Council (Grant number MR/M013227/1).
Version: | 0.4.6 |
Depends: | R (≥ 3.6.0), nlme, survival |
Imports: | cobs, doParallel, foreach, generics, ggplot2, graphics, lme4 (≥ 1.1-8), MASS, Matrix, mvtnorm, parallel, randtoolbox, Rcpp (≥ 0.12.7), stats, tibble, utils |
LinkingTo: | Rcpp, RcppArmadillo |
Suggests: | bindrcpp, dplyr, JM, joineR, knitr, rmarkdown, testthat |
Published: | 2023-01-20 |
DOI: | 10.32614/CRAN.package.joineRML |
Author: | Graeme L. Hickey [cre, aut], Pete Philipson [aut], Andrea Jorgensen [ctb], Ruwanthi Kolamunnage-Dona [aut], Paula Williamson [ctb], Dimitris Rizopoulos [ctb, dtc] (data/renal.rda, R/hessian.R, R/vcov.R), Alessandro Gasparini [aut], Medical Research Council [fnd] (Grant number: MR/M013227/1) |
Maintainer: | Graeme L. Hickey <graemeleehickey at gmail.com> |
BugReports: | https://github.com/graemeleehickey/joineRML/issues |
License: | GPL-3 | file LICENSE |
URL: | https://github.com/graemeleehickey/joineRML |
NeedsCompilation: | yes |
Citation: | joineRML citation info |
Materials: | README NEWS |
In views: | Survival |
CRAN checks: | joineRML results |
Reference manual: | joineRML.pdf |
Vignettes: |
joineRML and the broom package joineRML Technical details of joineRML |
Package source: | joineRML_0.4.6.tar.gz |
Windows binaries: | r-devel: joineRML_0.4.6.zip, r-release: joineRML_0.4.6.zip, r-oldrel: joineRML_0.4.6.zip |
macOS binaries: | r-release (arm64): joineRML_0.4.6.tgz, r-oldrel (arm64): joineRML_0.4.6.tgz, r-release (x86_64): joineRML_0.4.6.tgz, r-oldrel (x86_64): joineRML_0.4.6.tgz |
Old sources: | joineRML archive |
Reverse imports: | jmBIG |
Reverse suggests: | BCClong, broom |
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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.