nlmixr2autoinit: Automatic Generation of Initial Estimates for Population Pharmacokinetic Modeling

Provides automated methods for generating initial parameter estimates in population pharmacokinetic modeling. The pipeline integrates adaptive single-point methods, naive pooled graphic approaches, noncompartmental analysis methods, and parameter sweeping across pharmacokinetic models. It estimates residual unexplained variability using either data-driven or fixed-fraction approaches and assigns pragmatic initial values for inter-individual variability. These strategies are designed to improve model robustness and convergence in 'nlmixr2' workflows. For more details see Huang Z, Fidler M, Lan M, Cheng IL, Kloprogge F, Standing JF (2025) <doi:10.1007/s10928-025-10000-z>.

Version:	1.0.0
Depends:	nlmixr2data, R (≥ 4.0)
Imports:	nlmixr2, nlmixr2est, rxode2, dplyr, tidyr, crayon, purrr, knitr, magrittr, progressr, tibble, vpc
Published:	2025-11-13
DOI:	10.32614/CRAN.package.nlmixr2autoinit (may not be active yet)
Author:	Zhonghui Huang [aut, cre], Joseph Standing [ctb], Matthew Fidler [ctb], Frank Kloprogge [ctb]
Maintainer:	Zhonghui Huang <huangzhonghui22 at gmail.com>
BugReports:	https://github.com/ucl-pharmacometrics/nlmixr2autoinit/issues
License:	GPL (≥ 3)
URL:	https://github.com/ucl-pharmacometrics/nlmixr2autoinit
NeedsCompilation:	no
Language:	en-US
CRAN checks:	nlmixr2autoinit results

Documentation:

Reference manual:

nlmixr2autoinit.html , nlmixr2autoinit.pdf

Downloads:

Package source:	nlmixr2autoinit_1.0.0.tar.gz
Windows binaries:	r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries:	r-release (arm64): nlmixr2autoinit_1.0.0.tgz, r-oldrel (arm64): nlmixr2autoinit_1.0.0.tgz, r-release (x86_64): nlmixr2autoinit_1.0.0.tgz, r-oldrel (x86_64): nlmixr2autoinit_1.0.0.tgz

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