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Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>).
Version: | 3.0.1 |
Depends: | nlmixr2data, R (≥ 4.0) |
Imports: | backports, checkmate, cli, graphics, knitr, lbfgsb3c, lotri, magrittr, Matrix, methods, minqa, n1qn1 (≥ 6.0.1-12), nlme, Rcpp, rex, rxode2 (≥ 3.0.0), stats, symengine, utils |
LinkingTo: | BH, n1qn1 (≥ 6.0.1-12), lbfgsb3c (≥ 2024-3.5), lotri (≥ 0.5.0), Rcpp, RcppArmadillo (≥ 0.11.2.3.1), RcppEigen, rxode2 (≥ 3.0.0) |
Suggests: | broom.mixed, crayon, data.table, devtools, digest, dplyr (≥ 1.1.0), generics, nloptr, qs, sys, testthat, tibble, withr, xgxr, sfsmisc, minpack.lm, remotes |
Published: | 2024-10-22 |
DOI: | 10.32614/CRAN.package.nlmixr2est |
Author: | Matthew Fidler [aut, cre], Yuan Xiong [aut], Rik Schoemaker [aut], Justin Wilkins [aut], Wenping Wang [aut], Robert Leary [ctb], Mason McComb [ctb], Vipul Mann [aut], Mirjam Trame [ctb], Mahmoud Abdelwahab [ctb], Teun Post [ctb], Richard Hooijmaijers [aut], Hadley Wickham [ctb], Dirk Eddelbuettel [cph], Johannes Pfeifer [ctb], Robert B. Schnabel [ctb], Elizabeth Eskow [ctb], Emmanuelle Comets [ctb], Audrey Lavenu [ctb], Marc Lavielle [ctb], David Ardia [cph], Katharine Mullen [cph], Ben Goodrich [ctb] |
Maintainer: | Matthew Fidler <matthew.fidler at gmail.com> |
License: | GPL (≥ 3) |
URL: | https://github.com/nlmixr2/nlmixr2est, https://nlmixr2.github.io/nlmixr2est/ |
NeedsCompilation: | yes |
Language: | en-US |
Citation: | nlmixr2est citation info |
Materials: | NEWS |
CRAN checks: | nlmixr2est results |
Reference manual: | nlmixr2est.pdf |
Package source: | nlmixr2est_3.0.1.tar.gz |
Windows binaries: | r-devel: nlmixr2est_3.0.1.zip, r-release: nlmixr2est_3.0.1.zip, r-oldrel: nlmixr2est_3.0.1.zip |
macOS binaries: | r-release (arm64): nlmixr2est_3.0.1.tgz, r-oldrel (arm64): nlmixr2est_3.0.1.tgz, r-release (x86_64): nlmixr2est_3.0.1.tgz, r-oldrel (x86_64): nlmixr2est_3.0.1.tgz |
Old sources: | nlmixr2est archive |
Reverse imports: | babelmixr2, nlmixr2, nlmixr2extra, nlmixr2lib, nlmixr2plot, xpose.nlmixr2 |
Please use the canonical form https://CRAN.R-project.org/package=nlmixr2est to link to this page.
These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.