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nlmixr2extra: Nonlinear Mixed Effects Models in Population PK/PD, Extra Support Functions

Fit and compare nonlinear mixed-effects models in differential equations with flexible dosing information commonly seen in pharmacokinetics and pharmacodynamics (Almquist, Leander, and Jirstrand 2015 <doi:10.1007/s10928-015-9409-1>). Differential equation solving is by compiled C code provided in the 'rxode2' package (Wang, Hallow, and James 2015 <doi:10.1002/psp4.12052>). This package is for support functions like preconditioned fits <doi:10.1208/s12248-016-9866-5>, boostrap and stepwise covariate selection.

Version: 3.0.1
Depends: R (≥ 4.0)
Imports: checkmate, cli (≥ 3.4.0), crayon, data.table, digest, dplyr, ggplot2, ggtext, knitr, lotri, methods, nlme, nlmixr2est (≥ 2.1.1), Rcpp, rxode2 (≥ 2.0.10), stats, symengine, utils
LinkingTo: Rcpp, RcppArmadillo
Suggests: brms, nlmixr2data, testthat (≥ 3.0.0), withr, devtools
Published: 2024-10-29
DOI: 10.32614/CRAN.package.nlmixr2extra
Author: Matthew Fidler ORCID iD [aut, cre], Vipul Mann [aut], Vishal Sarsani ORCID iD [aut], Christian Bartels [ctb], Bill Denney ORCID iD [aut]
Maintainer: Matthew Fidler <matthew.fidler at gmail.com>
BugReports: https://github.com/nlmixr2/nlmixr2extra/issues/
License: GPL (≥ 3)
URL: https://nlmixr2.github.io/nlmixr2extra/, https://github.com/nlmixr2/nlmixr2extra/
NeedsCompilation: yes
Citation: nlmixr2extra citation info
Materials: README NEWS
CRAN checks: nlmixr2extra results

Documentation:

Reference manual: nlmixr2extra.pdf

Downloads:

Package source: nlmixr2extra_3.0.1.tar.gz
Windows binaries: r-devel: nlmixr2extra_3.0.1.zip, r-release: nlmixr2extra_3.0.1.zip, r-oldrel: nlmixr2extra_3.0.1.zip
macOS binaries: r-release (arm64): nlmixr2extra_3.0.1.tgz, r-oldrel (arm64): nlmixr2extra_3.0.1.tgz, r-release (x86_64): nlmixr2extra_3.0.1.tgz, r-oldrel (x86_64): nlmixr2extra_3.0.1.tgz
Old sources: nlmixr2extra archive

Reverse dependencies:

Reverse imports: nlmixr2, nlmixr2plot, nlmixr2rpt

Linking:

Please use the canonical form https://CRAN.R-project.org/package=nlmixr2extra to link to this page.

These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.