admixr2: Aggregate Data Modelling

Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector and covariance matrix per study) rather than individual-level data. Integrates with the 'nlmixr2'/'rxode2' ecosystem via three estimation methods: a First-Order ('FO') analytical estimator, a Monte Carlo (MC) estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.

Version:	0.1.0
Depends:	R (≥ 4.1.0)
Imports:	checkmate, digest, nlmixr2est, nloptr, qs2, randtoolbox, Rcpp, rxode2
LinkingTo:	Rcpp, RcppEigen
Suggests:	expm, furrr, future, ggplot2, knitr, mnormt, nlmixr2, patchwork, rmarkdown, testthat (≥ 3.0.0)
Published:	2026-06-02
DOI:	10.32614/CRAN.package.admixr2 (may not be active yet)
Author:	H. van de Beek [aut, cre], P.A.J. Välitalo [aut], L.B. Zwep [aut], J.G.C. van Hasselt [aut]
Maintainer:	H. van de Beek <h.van.de.beek at lacdr.leidenuniv.nl>
BugReports:	https://github.com/LeidenPharmacology/admixr2/issues
License:	GPL (≥ 3)
URL:	https://leidenpharmacology.github.io/admixr2/, https://github.com/LeidenPharmacology/admixr2
NeedsCompilation:	yes
Citation:	admixr2 citation info
Materials:	README, NEWS
CRAN checks:	admixr2 results

Documentation:

Reference manual:	admixr2.html , admixr2.pdf
Vignettes:	Getting started with admixr2 (source, R code)

Downloads:

Package source:	admixr2_0.1.0.tar.gz
Windows binaries:	r-devel: not available, r-release: not available, r-oldrel: not available
macOS binaries:	r-release (arm64): admixr2_0.1.0.tgz, r-oldrel (arm64): admixr2_0.1.0.tgz, r-release (x86_64): admixr2_0.1.0.tgz, r-oldrel (x86_64): admixr2_0.1.0.tgz

Linking:

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