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nlmixr2scm: Stepwise Covariate Modeling for 'nlmixr2' Models

Stepwise covariate modeling (SCM) for nonlinear mixed-effects models fitted with 'nlmixr2'. Forward inclusion and backward elimination are driven by likelihood-ratio tests, and the covariate terms are generated inside the model body, so continuous covariates are centered and categorical covariates expanded into indicator columns without editing the model by hand. Candidate fits can be cached and resumed, fitted in parallel, and reviewed through per-step and all-candidate summary tables. The approach follows Jonsson and Karlsson (1998) <doi:10.1023/A:1011970125687>, and the implementation in 'Perl-speaks-NONMEM' described by Lindbom, Ribbing and Jonsson (2004) <doi:10.1016/j.cmpb.2003.11.003>.

Version: 0.4.1
Depends: R (≥ 4.1)
Imports: checkmate, cli (≥ 3.4.0), data.table, lotri, nlme, nlmixr2est (≥ 7.0.0), nlmixr2utils (≥ 0.3), rxode2 (≥ 5.0.0), stats, tools, utils
Suggests: future, knitr, nlmixr2data, pkgload, rmarkdown, testthat (≥ 3.0.0), withr
Published: 2026-09-30
DOI: 10.32614/CRAN.package.nlmixr2scm
Author: Justin Wilkins ORCID iD [aut, cre, cph], Matthew Fidler ORCID iD [aut], Yaping Liu ORCID iD [aut], Bill Denney ORCID iD [aut], Vipul Mann [aut], Vishal Sarsani ORCID iD [aut], Christian Bartels [ctb]
Maintainer: Justin Wilkins <justin.wilkins at occams.com>
BugReports: https://github.com/nlmixr2/nlmixr2scm/issues
License: GPL (≥ 3)
URL: https://github.com/nlmixr2/nlmixr2scm
NeedsCompilation: no
Materials: README, NEWS
CRAN checks: nlmixr2scm results

Documentation:

Reference manual: nlmixr2scm.html , nlmixr2scm.pdf
Vignettes: Stepwise Covariate Modelling with runSCM() (source)

Downloads:

Package source: nlmixr2scm_0.4.1.tar.gz
Windows binaries: r-devel: nlmixr2scm_0.4.1.zip, r-release: nlmixr2scm_0.4.zip, r-oldrel: nlmixr2scm_0.4.1.zip
macOS binaries: r-release (arm64): nlmixr2scm_0.4.tgz, r-oldrel (arm64): nlmixr2scm_0.4.tgz, r-release (x86_64): nlmixr2scm_0.4.1.tgz, r-oldrel (x86_64): nlmixr2scm_0.4.1.tgz
Old sources: nlmixr2scm archive

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.