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spatialGE: Visualization and Analysis of Spatial Heterogeneity in Spatially-Resolved Gene Expression

Visualization and analysis of spatially resolved transcriptomics data. The 'spatialGE' R package provides methods for visualizing and analyzing spatially resolved transcriptomics data, such as 10X Visium, CosMx, or csv/tsv gene expression matrices. It includes tools for spatial interpolation, autocorrelation analysis, tissue domain detection, gene set enrichment, and differential expression analysis using spatial mixed models.

Version: 1.2.0
Imports: arrow, BiocParallel, concaveman, ComplexHeatmap, data.table, DelayedArray, DelayedMatrixStats, dynamicTreeCut, dplyr, EBImage, ggforce, ggplot2, ggpolypath, ggrepel, gstat, GSVA, hdf5r, jpeg, jsonlite, khroma (≥ 1.6.0), magrittr, Matrix, MASS, methods, parallel, png, RColorBrewer, Rcpp (≥ 1.0.7), readr, readxl, rlang, scales, sctransform, sfsmisc, sf, sp, spaMM, spdep, stats, stringr, tibble, tidyr, utils, uwot, wordspace
LinkingTo: Rcpp, RcppEigen, RcppProgress
Suggests: geoR, ggpubr, janitor, kableExtra, knitr, msigdbr, progress, rmarkdown, rpart, R.utils, scSpatialSIM, spatstat, SeuratObject, tidyverse, testthat (≥ 3.0.0)
Published: 2025-05-13
DOI: 10.32614/CRAN.package.spatialGE
Author: Oscar Ospina ORCID iD [aut, cre], Alex Soupir ORCID iD [aut], Brooke Fridley ORCID iD [aut], Satija Lab [cph] (Copyright holder of code fragments from Seurat function FindVariableFeatures)
Maintainer: Oscar Ospina <oscar.ospina at jhmi.edu>
License: MIT + file LICENSE
Copyright: ins/COPYRIGHT
NeedsCompilation: yes
Materials: README NEWS
CRAN checks: spatialGE results [issues need fixing before 2025-05-27]

Documentation:

Reference manual: spatialGE.pdf
Vignettes: spatialge_tutorial_main (source, R code)

Downloads:

Package source: spatialGE_1.2.0.tar.gz
Windows binaries: r-devel: spatialGE_1.2.0.zip, r-release: spatialGE_1.2.0.zip, r-oldrel: not available
macOS binaries: r-release (arm64): spatialGE_1.2.0.tgz, r-oldrel (arm64): spatialGE_1.2.0.tgz, r-release (x86_64): spatialGE_1.2.0.tgz, r-oldrel (x86_64): spatialGE_1.2.0.tgz

Linking:

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These binaries (installable software) and packages are in development.
They may not be fully stable and should be used with caution. We make no claims about them.